Powering new therapeutics with precision mitochondrial editing

Arlie Strub, June 3, 2025June 3, 2025, Uncategorized, 0

Nature Biotechnology, Published online: 03 June 2025; doi:10.1038/s41587-025-02693-xMore precise base editors make mitochondrial DNA editing efficient enough to model disease and correct pathogenic mutations in rodents, but they are slow to move into clinical trials…
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Resurrecting a miniature Cas9 ancestor for genome and epigenome editing A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes

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